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Elbdkiny, M. N.
- Spectrophotometric Determination of Aciclovir, Cefepirne Hydrochloride, Etamsylate and Metoclopramide Hydrochloride Using 1,10 Phenanthroline - Fe(lll) Reagent
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Authors
Affiliations
1 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EG
1 Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, EG
Source
Scientia Pharmaceutica, Vol 72, No 1 (2004), Pagination: 73-86Abstract
A simple, rapid, sensitive and accurate method for the determination of aciclovir, cefepime HCl, etamsylate and metoclopramide HCl in pure form and in pharmaceutical formulations is developed. The method is based on the fomabon of tris(o-phenanthroline) iron(II) complex (Ferroin) upon the reaction of the cited drugs wrth iron(III)-o-phenanthroline mixture. The ferroin complex is colorimetrically measured at λmax 510 nm against a reagent blank. 0ptimization of the experimental conditions is described. Beer's law is obeyed in the concentration range from 0.25-30 μg ml-1 with molar absorpitivities (ε) ranging from 4.796 × 103-9.512 × 104 L.mol-1.cm-1 and Sandell sensitivities (S) of 2.129 × 10-3-34.5 × 10-3 μg cm-2. The developed method is applied successfully for the determination of the cited drugs in pure forms and in the corresponding pharmaceutical formulations wtthout any interferences from common excipients.Keywords
Spectrophotometry; 1,10 - Phenanthroline - Fe(III) Reagent; Pure Forms; Pharmaceutical Formulations.
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